Apolipoprotein E and mortality in African-Americans and Yoruba
نویسندگان
چکیده
منابع مشابه
Obesity and 10-year mortality in very old African Americans and Yoruba-Nigerians: exploring the obesity paradox.
BACKGROUND To compare the effect of obesity and related risk factors on 10-year mortality in two cohorts of older adults of African descent; one from the United States and one from Nigeria. METHODS Study participants were community residents aged 70 or older of African descent living in Indianapolis, Indiana (N = 1,269) or Ibadan, Nigeria (1,197). We compared survival curves between the two c...
متن کاملApolipoprotein E and cognition in community-based samples of African Americans and Caucasians.
To compare relative frequencies of apolipo-protein E (APOE) alleles in African-American and Caucasian populations and test associations with cognition, we studied two community-based samples: one of 253 African Americans and another of 466 Caucasians age 60-84 years. Logistic regression, adjusting for age, sex, education, and history of hypertension and diabetes was used to associate APOE with ...
متن کاملAssociation of apolipoprotein E genotype and Alzheimer disease in African Americans.
BACKGROUND Alzheimer disease (AD) is the most frequent cause of dementia. Even though the incidence of AD in the African American population is similar to or higher than that in persons of European descent, AD in African Americans is understudied. Identification of genetic risk factors in African Americans is essential for understanding the etiology of AD. OBJECTIVE To determine the effect of...
متن کاملA comparison of cardiovascular disease risk factor biomarkers in African Americans and Yoruba Nigerians.
OBJECTIVE Classical risk factors for coronary artery disease are changing in the developing world while rates of cardiovascular disease are increasing in these populations. Newer risk factors have been identified for cardiovascular disease, but these have been rarely examined in elderly populations and not those of developing countries. METHODS This study was a cross-sectional comparison from...
متن کاملGenetic Influences on Plasma Homocysteine Levels in African Americans and Yoruba Nigerians.
Plasma homocysteine, a metabolite involved in key cellular methylation processes seems to be implicated in cognitive functions and cardiovascular health with its high levels representing a potential modifiable risk factor for Alzheimer's disease (AD) and other dementias. A better understanding of the genetic factors regulating homocysteine levels, particularly in non-white populations, may help...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2003
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2003-5505